Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine.

ABSTRACT: Migraine is a primary headache disorder which has complex neurogenic pathophysiological mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell couplings in the migraine target tissue are very effective interfaces between the central nervous system and the immune system. These couplings fall into three categories: intimacy, cross-talk and a shared fate. Acting as the immediate call-center of the neuroimmune system, mast cells play fundamental roles in migraine pathophysiology. Considerable evidence shows that neuroinflammation in the meninges is the key element resulting in the sensitization of trigeminal nociceptors. The successive events such as neuropeptide release, vasodilation, plasma protein extravasation, and mast cell degranulation that form the basi

SUBMITTER: Koyuncu Irmak D 

PROVIDER: S-EPMC6460506 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature