A game of hide and seq: Identification of parallel Y-STR evolution in deep-rooting pedigrees.

ABSTRACT: Short tandem repeats on the Y-chromosome (Y-STRs) are common DNA polymorphisms useful for genetic genealogy, population and evolutionary genetics, human genetics, pathology and forensic sciences. It is important to identify all Y-STR variants and to have knowledge of Y-STR mutation rates in order to correctly estimate the time to the most recent common ancestor (tMRCA) between paternally related individuals. When capillary electrophoresis (CE) is performed to analyze genealogical pairs, Y-STR sequence variations remain hidden when the number of repeats is identical. These hidden variations could be due to parallel Y-STR changes or modifications (PM) that occur independently in different lineages leading to alleles with identical number of repeats. In this study, we detect for the first tim

SUBMITTER: Claerhout S 

PROVIDER: S-EPMC6460584 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature