Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis.

ABSTRACT:

Background

Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of breast cancer (BC). However, this relationship remains controversial.

Methods

We conducted a meta-analysis of seven studies to assess the associations between BRCA1 rs799917 and rs1799966 and BC risk, with the aim of more accurately determining the potential correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the correlation of rs799917 and rs1799966 with BC risk.

Results

There was no overall correlation between BRCA1 rs799917 and BC risk (TT vs CC: OR = 0.87, 95% CI = 0.66-1.16; CT vs CC: OR = 1.02, 95% CI = 0.89-1.15; dominant model: OR = 0.99, 95% CI = 0.88-1.11; recessive model: OR = 0.87, 95% CI = 0.65-

SUBMITTER: Yang M 

PROVIDER: S-EPMC6460623 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature