A splice donor variant in CCDC189 is associated with asthenospermia in Nordic Red dairy cattle.

ABSTRACT:

Background

Cattle populations are highly amenable to the genetic mapping of male reproductive traits because longitudinal data on ejaculate quality and dense microarray-derived genotypes are available for thousands of artificial insemination bulls. Two young Nordic Red bulls delivered sperm with low progressive motility (i.e., asthenospermia) during a semen collection period of more than four months. The bulls were related through a common ancestor on both their paternal and maternal ancestry. Thus, a recessive mode of inheritance of asthenospermia was suspected.

Results

Both bulls were genotyped at 54,001 SNPs using the Illumina BovineSNP50 Bead chip. A scan for autozygosity revealed that they were identical by descent for a 2.98 Mb segment located on bovine chromosome 25.

SUBMITTER: Iso-Touru T 

PROVIDER: S-EPMC6460654 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature