Screening of differentially expressed microRNAs of essential hypertension in Uyghur population.

ABSTRACT:

Background

Essential hypertension can cause many kinds of cardiovascular diseases. The pathogenesis of essential hypertension is very complex, and the mechanism is still unclear. The microRNAs have been identified as novel biomarkers for pre-diagnosis and prognosis of hypertension. However, the kinds of microRNAs that can be used as specific biomarkers for hypertension are unknown.

Methods and results

Plasma samples were isolated from Uyghur subjects with essential hypertension and the healthy individuals. Microarray was used to identify differentially expressed microRNAs. The microarray data were clustered and annotated with online software. The target genes of differentially expressed microRNAs were also analyzed. The microarray results were further verified by quantitativ

SUBMITTER: Ye Y 

PROVIDER: S-EPMC6460779 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature