Salivary LDOC1 is a gender-difference biomarker of oral squamous cell carcinoma.

ABSTRACT:

Background

The X-linked tumor suppressor gene LDOC1 is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary LDOC1 as a biomarker of oral cancer.

Methods

We determined the expression levels of LDOC1 in the saliva of oral squamous cell carcinoma (OSCC) subjects, and investigated its correlation with various clinicopathological characteristics. The expression levels of salivary LDOC1 were detected in 53 OSCC subjects and 43 healthy controls using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. We used Fisher's exact test to analyze the correlations between ex

SUBMITTER: Liu CJ 

PROVIDER: S-EPMC6461027 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature