Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking.

ABSTRACT:

Introduction

The placenta controls nutrient transfer between mother and fetus via membrane transporters. Appropriate transplacental passage of nutrients is essential for fetal growth and development. We investigated whether transporter transcript levels in human placenta-liver pairs from first and early second trimester pregnancies exhibit gestational age- or fetal sex-specific profiles and whether these are dysregulated by maternal smoking.

Methods

In a step-change for the field, paired placenta and fetal livers from 54 electively terminated, normally-progressing pregnancies (7-20 weeks of gestation, Scottish Advanced Fetal Research Study, REC 15/NS/0123) were sexed and cigarette smoking-exposure confirmed. Thirty-six nutrient transporter transcripts were quantified using R

SUBMITTER: Walker N 

PROVIDER: S-EPMC6461130 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature