A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats.

ABSTRACT: It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over 40 years, compared with the laboratory mouse of 4 years. We investigated the differences in the biochemical composition of mitochondria between bat and mouse species. We used proteomics and ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry lipidomics, to interrogate mitochondrial fractions prepared from Mus musculus and Pipistrellus pipistrellus brain and skeletal muscle. Fatty acid binding protein 3 was found at different levels in mouse and bat muscle mitochondria and its orthologues wer

SUBMITTER: Pollard AK 

PROVIDER: S-EPMC6461166 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature