Rich-club connectivity, diverse population coupling, and dynamical activity patterns emerging from local cortical circuits.

ABSTRACT: Experimental studies have begun revealing essential properties of the structural connectivity and the spatiotemporal activity dynamics of cortical circuits. To integrate these properties from anatomy and physiology, and to elucidate the links between them, we develop a novel cortical circuit model that captures a range of realistic features of synaptic connectivity. We show that the model accounts for the emergence of higher-order connectivity structures, including highly connected hub neurons that form an interconnected rich-club. The circuit model exhibits a rich repertoire of dynamical activity states, ranging from asynchronous to localized and global propagating wave states. We find that around the transition between asynchronous and localized propagating wave states, our model quantit

SUBMITTER: Gu Y 

PROVIDER: S-EPMC6461296 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature