Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype.

ABSTRACT:

Purpose

To investigate the association between metabolic syndrome (MetS) and risk of breast cancer mortality by menopausal status, obesity, and subtype.

Methods

Data from 94,555 women free of cancer at baseline in the National Institute of Health-American Association of Retired Persons Diet and Health Study cohort (NIH-AARP) were used to investigate the prospective associations of baseline MetS and components with risk of breast cancer mortality using Cox proportional hazard regression models adjusted for baseline behavioral and demographic covariates.

Results

During a mean follow-up duration of 14 years, 607 women in the cohort died of breast cancer. Overall, MetS was associated with a 73% increased risk of breast cancer mortality (HR 1.73; 95% CI 1.09-2.75); the ass

SUBMITTER: Dibaba DT 

PROVIDER: S-EPMC6461393 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature