ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.

ABSTRACT:

Rationale

Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates the transcription factor, ATF6 (activating transcription factor 6α), an inducer of genes that enhance protein folding and restore ER proteostasis. Because of increased protein synthesis, it is possible that protein folding and ER proteostasis are challenged during cardiac myocyte growth. However, it is not known whether ATF6 is activated, and if so, what its function is during hypertrophic growth of cardiac myocytes.

Objective

To examine the activity and function of ATF6 during cardiac hypertrophy.

Methods and results

We found that ER stress and ATF6 were activated and ATF6 target genes were induced in mice subjected to an acute model of transverse aortic constriction, or to free

SUBMITTER: Blackwood EA 

PROVIDER: S-EPMC6461398 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature