Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.

ABSTRACT: Obesity-related adverse health consequences occur predominately in individuals with upper body fat distribution commonly associated with increased central adiposity. Visceral adipose tissue accumulation is described to be the greatest driver of obesity-induced inflammation, however evidence also supports that the intestines fundamentally contribute to the development of obesity-induced metabolic disease. The visceral adipose depot shares the same vasculature and lymph drainage as the small intestine. We hypothesize that the visceral lymph node, which drains adipose tissue and the gastrointestinal tract, is central to the exacerbation of systemic pro-inflammation. Male C57BL/6 mice were fed CHOW or high fat diet (HFD) for 7 weeks. At termination the mesenteric depot, visceral lymph node and

SUBMITTER: Magnuson AM 

PROVIDER: S-EPMC6461448 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature