The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications.

ABSTRACT: Complex and bidirectional interactions between the renin-angiotensin system (RAS) and autonomic nervous system have been well established for cardiovascular regulation under both physiological and pathophysiological conditions. Most research to date has focused on deleterious effects of components of the vasoconstrictor arm of the RAS on cardiovascular autonomic control, such as renin, angiotensin II, and aldosterone. The recent discovery of prorenin and the prorenin receptor have further increased our understanding of RAS interactions in autonomic brain regions. Therapies targeting these RAS components, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers, are commonly used for treatment of hypertension and cardiovascular diseases, with blood pressure-l

SUBMITTER: Miller AJ 

PROVIDER: S-EPMC6461499 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature