Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells.

ABSTRACT: Glioblastoma (GBM) is the most aggressive brain tumor and resistant to current available therapeutics, such as radiation. To improve the clinical efficacy, it is important to understand the cellular mechanisms underlying tumor responses to radiation. Here, we investigated long-term cellular responses of human GBM cells to ionizing radiation. Comparing to the initial response within 12 hours, gene expression modulation at 7 days after radiation is markedly different. While genes related to cell cycle arrest and DNA damage responses are mostly modulated at the initial stage; immune-related genes are specifically affected as the long-term effect. This later response is associated with increased cellular senescence and inhibition of transcriptional coactivator with PDZ-binding motif (TAZ). Mec

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6461515 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature