Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis.

ABSTRACT:

Objectives

This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers.

Background

Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to atherosclerotic plaque morphology and composition, disease activity needs to be evaluated.

Methods

We screened 3 nanobody radiotracers targeted to different biomarkers of atherosclerosis progression, namely vascular cell adhesion molecule (VCAM)-1, lectin-like oxidized low-density lipoprotein receptor (LOX)-1, and macrophage mannose receptor (MMR)

SUBMITTER: Senders ML 

PROVIDER: S-EPMC6461528 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature