Connectome analysis of functional and structural hemispheric brain networks in major depressive disorder.

ABSTRACT: Neuroimaging studies have shown topological disruptions of both functional and structural whole-brain networks in major depressive disorder (MDD). This study examined common and specific alterations between these two types of networks and whether the alterations were differentially involved in the two hemispheres. Multimodal MRI data were collected from 35 MDD patients and 35 healthy controls, whose functional and structural hemispheric networks were constructed, characterized, and compared. We found that functional brain networks were profoundly altered at multiple levels, while structural brain networks were largely intact in patients with MDD. Specifically, the functional alterations included decreases in intra-hemispheric (left and right) and inter-hemispheric (heterotopic) functional

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6461612 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature