A molecular biomarker for prediction of clinical outcome in children with ASD, constipation, and intestinal inflammation.

ABSTRACT: In children with autism spectrum disorder (ASD) who present to the gastroenterologist with chronic constipation on a background of colonic inflammation, we have identified two distinct clinical subtypes: (1) patients who experience a sustained state of GI symptomatic remission while on maintenance anti-inflammatory therapy (fast responders) and, (2) those with recurrent right-sided fecal loading requiring regular colon cleanouts during treatment for enterocolitis (slow responders). We hypothesized that a detailed molecular analysis of tissue from the affected region of the colon would provide mechanistic insights regarding the fast versus slow response to anti-inflammatory therapy. To test this, ascending colon biopsy tissues from 35 children with ASD (20 slow responders and 15 fast respon

SUBMITTER: Walker SJ 

PROVIDER: S-EPMC6461625 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature