Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice.

ABSTRACT:

Objective

Maternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis.

Methods

Dams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD. At 14 weeks of age, offspring were subjected to 2.5% DSS in drinking water for 5 days, followed by 5 days of recovery.

Results

Offspring from maternal HFD had higher body weight gain before DSS induction and had higher liver and fat weights with increased adipocyte size at necropsy. When subjected to D

SUBMITTER: Bibi S 

PROVIDER: S-EPMC6461699 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature