Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition.

ABSTRACT: High mortality after discharge from hospital following acute illness has been observed among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be amenable to intervention to reduce risk are unknown. We performed a nested case-control study among HIV-uninfected children aged 2-59 months treated for complicated SAM according to WHO recommendations at four Kenyan hospitals. Blood was drawn from 1778 children when clinically judged stable before discharge from hospital. Cases were children who died within 60 days. Controls were randomly selected children who survived for one year without readmission to hospital. Untargeted proteomics, total protein, cytokines and chemokines, and leptin were assayed in plasma and corresponding biological processes determined. Among 121

SUBMITTER: Njunge JM 

PROVIDER: S-EPMC6461700 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature