The Impact of Alzheimer's Disease on the Resting State Functional Connectivity of Brain Regions Modulating Pain: A Cross Sectional Study.

ABSTRACT:

Background

It is currently unknown why people with Alzheimer's disease (AD) receive less pain medication and report pain less frequently.

Objective

The purpose of this study was to determine the impact of AD on thermal psychophysics and resting-state functional connectivity (RSFC) among sensory, affective, descending modulatory, and default mode structures.

Methods

Controls (n = 23, 13 = female) and age-matched people with AD (n = 23, 13 = females) underwent psychophysical testing to rate perceptions of warmth, mild, and moderate pain and then completed resting-state fMRI. Between groups analysis in psychophysics and RSFC were conducted among pre-defined regions of interest implicated in sensory and affective dimensions of pain, descending pain modulation, and the def

SUBMITTER: Monroe TB 

PROVIDER: S-EPMC6461741 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature