Sector Retinitis Pigmentosa caused by mutations of the RHO gene.

ABSTRACT:

Background

Sector retinitis pigmentosa (RP) is an atypical form of RP in which only one or two quadrants of the retina are involved. The objectives of this study were to report the results of a molecular screening of five unrelated Chinese patients with sector RP and describe the clinical features observed in patients with RHO mutations.

Methods

Five probands that were clinically diagnosed with sector RP were recruited for genetic analysis. They underwent ophthalmic examinations, including best corrected visual acuity, fundus examination, visual field examinations, and electroretinography. A combination of molecular screening methods, including the targeted next-generation sequencing (TES) and sanger-DNA sequencing of RHO, were used to detect mutations. In silico programs we

SUBMITTER: Xiao T 

PROVIDER: S-EPMC6461763 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature