Altered frontostriatal white matter microstructure is associated with familial alcoholism and future binge drinking in adolescence.

ABSTRACT: Adolescence is a time of significant neurobiological development, including changes in white matter microstructure. Familial alcoholism and adolescent binge-drinking have both been associated with altered white matter microstructure; however, the temporal nature of these effects, and their interaction, is unclear. Using diffusion-weighted imaging and voxel-wise multilevel modeling, the effects of familial alcoholism and future binge-drinking on white matter microstructural development were assessed in 45 adolescents, who went on to binge-drink (but were alcohol-naive at baseline), and 68 adolescents, who remained largely alcohol-naive, all with varying degrees of familial alcoholism. Both future binge-drinking and familial alcoholism were associated with altered frontostriatal white matter

SUBMITTER: Jones SA 

PROVIDER: S-EPMC6461789 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature