Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection.

ABSTRACT:

Background

Impairment of the blood-brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders (HAND). Recent research suggests an important role for the Sonic hedgehog (Shh) signaling pathway in the maintenance of BBB integrity under both physiological and pathological conditions.

Methods

In the present study, we sought to examine the expression of Shh and its downstream effectors in relation to brain pericytes and BBB integrity in HIV-infected humans and rhesus macaques infected with simian immunodeficiency virus (SIV), an animal model of HIV infection and CNS disease. Cortical brain tissues from uninfected (n = 4) and SIV-infected macaques with (SIVE, n = 6) or without encephalitis (SIVnoE, n = 4)

SUBMITTER: Bohannon DG 

PROVIDER: S-EPMC6461821 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature