High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases.

ABSTRACT:

Background

Patients with borderline resectable colorectal liver metastases (CRLM) frequently receive neoadjuvant chemotherapy (NC) to reduce tumour burden, thus making surgical resection feasible. Even though NC can induce severe liver injury, most studies investigating tissue-based prognostic markers focus on tumour tissue. Here, we assessed the prognostic significance of pyruvate-dehydrogenase-kinase isoenzyme 4 (PDK4) within liver tissue of patients undergoing surgical resection due to CRLM.

Methods

Transcript levels of hypoxia-adaptive genes (such as PDK isoenzymes) were assessed in the tissue of healthy liver, corresponding CRLM, healthy colon mucosa and corresponding tumour. Uni- and multivariate analyses were performed. Responses to chemotherapy upon up- or down-regul

SUBMITTER: Strowitzki MJ 

PROVIDER: S-EPMC6461828 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature