MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer.

ABSTRACT:

Background

MicroRNAs are potent post-transcriptional regulators involved in all hallmarks of cancer. Mir-196a is transcribed from two loci and has been implicated in a wide range of developmental and pathogenic processes, with targets including Hox, Fox, Cdk inhibitors and annexins. Genetic variants and altered expression of MIR196A are associated with risk and progression of multiple cancers including breast cancer, however little is known about the regulation of the genes encoding this miRNA, nor the impact of variants therein.

Methods

Genomic data and chromatin interaction analysis were used to discover functional promoter and enhancer elements for MIR196A. Expression data were used to associate MIR196A with mechanisms of resistance, breast cancer subtypes and prognosis.<

SUBMITTER: Milevskiy MJG 

PROVIDER: S-EPMC6461839 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature