Genome-wide association study of germline variants and breast cancer-specific mortality.

ABSTRACT:

Background

We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

Methods

Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP).

Results

We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10^-8. For ER-positive disease, the most significantly associated variant was

SUBMITTER: Escala-Garcia M 

PROVIDER: S-EPMC6461853 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature