Epistasis regulates the developmental stability of the mouse craniofacial shape.

ABSTRACT: Fluctuating asymmetry is a classic concept linked to organismal development. It has traditionally been used as a measure of developmental instability, which is the inability of an organism to buffer environmental fluctuations during development. Developmental stability has a genetic component that influences the final phenotype of the organism and can lead to congenital disorders. According to alternative hypotheses, this genetic component might be either the result of additive genetic effects or a by-product of developmental gene networks. Here we present a genome-wide association study of the genetic architecture of fluctuating asymmetry of the skull shape in mice. Geometric morphometric methods were applied to quantify fluctuating asymmetry: we estimated fluctuating asymmetry as Mahalan

SUBMITTER: Varon-Gonzalez C 

PROVIDER: S-EPMC6461946 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature