Unraveling the role of genetics in the pathogenesis of diabetic retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented i

SUBMITTER: Sharma A 

PROVIDER: S-EPMC6461978 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature