Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia.

ABSTRACT: Although some studies have suggested that relapse may be associated with antipsychotic treatment resistance in schizophrenia, the number and quality of studies is limited. The current analysis included patients with a diagnosis of first-episode schizophrenia or schizoaffective disorder who met the following criteria: (1) referral to the First-Episode Psychosis Program between 2003 and 2013; (2) treatment with an oral second-generation antipsychotic according to a standardized treatment algorithm; (3) positive symptom remission; (4) subsequent relapse (i.e., second episode) in association with non-adherence; and (5) reintroduction of antipsychotic treatment with the same agent used to achieve response in the first episode. The following outcomes were used as an index of antipsychotic treatm

SUBMITTER: Takeuchi H 

PROVIDER: S-EPMC6462044 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature