Venous thromboembolism in a large cohort of children with acute lymphoblastic leukemia: Risk factors and effect on prognosis.

ABSTRACT:

Background

Venous thromboembolism (VTE) is relatively common in children with acute lymphoblastic leukemia (ALL). Thrombotic risk factors in ALL are asparaginase and steroids. However, within the ALL populations treated on the same regimen, it is less clear which other risk factors play a role. Furthermore, few data are available on the effect of VTE on ALL outcomes.

Methods

In 778 children (1-18 years) with newly diagnosed precursor-B-lineage or T-lineage ALL, treated in the Dutch Childhood Oncology Group (DCOG) ALL-10 protocol in the Netherlands (October 2004 to April 2013), we conducted a nested case control study with 59 VTE cases and 118 controls to identify risk factors for VTE.

Results

Fifty-nine of 778 ALL patients developed VTE (7.6%), with cerebral venous si

SUBMITTER: Klaassen ILM 

PROVIDER: S-EPMC6462738 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature