Liver stiffness and thrombin generation in compensated cirrhosis.

ABSTRACT:

Background

Decompensated cirrhosis is associated with coagulation abnormalities that can increase the risk of thrombosis and bleeding. It is unclear precisely when these abnormalities arise and whether they are exacerbated as compensated cirrhosis progresses. Transient elastography using FibroScan generates liver stiffness measurements (LSM) that associate with portal hypertension, clinical outcomes and provides prognostic information at an earlier stage than traditional liver function scores eg, MELD score.

Objective

To characterize thrombin generation in patients with compensated cirrhosis and to determine whether parameters of coagulation change throughout compensated cirrhosis, staged using LSM.

Patients/methods

Blood samples were collected from well-compensated c

SUBMITTER: Dillon A 

PROVIDER: S-EPMC6462746 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature