Exposure to vitamin k antagonists and kidney function decline in patients with atrial fibrillation and chronic kidney disease.

ABSTRACT:

Background

Exposure to vitamin K antagonists (VKA) has been suggested to accelerate progression of chronic kidney disease (CKD) but robust clinical data are currently lacking.

Methods

We retrospectively evaluated the impact of VKA exposure on kidney function in patients with atrial fibrillation (AF) and CKD stage 3/4. Patients were prospectively followed within a primary care electronic database (median follow-up of 1.45 years). The kidney function trajectory over time, defined as the annualized change in estimated glomerular filtration rate (eGFR), was analyzed with linear mixed-effects regression including propensity score adjustment.

Results

14 432 patients (median age 78 years, median CHA ₂ DS ₂-VASc score 4 points) contributed 97 792 eGFR me

SUBMITTER: Posch F 

PROVIDER: S-EPMC6462762 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature