Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease.

ABSTRACT: We studied the dynamic functional connectivity profile of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) compared to controls, how it differs between the two dementia subtypes, and a possible relation between dynamic connectivity alterations and temporally transient clinical symptoms in DLB. Resting state fMRI data from 31 DLB, 29 AD, and 31 healthy control participants were analyzed using dual regression to determine between-network functional connectivity. Subsequently, we used a sliding window approach followed by k-means clustering and dynamic network analyses to study dynamic functional connectivity. Dynamic connectivity measures that showed significant group differences were tested for correlations with clinical symptom severity. Our results show that AD and DLB patient

SUBMITTER: Schumacher J 

PROVIDER: S-EPMC6462776 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature