BMI-related cortical morphometry changes are associated with altered white matter structure.

ABSTRACT:

Background

While gross measures of brain structure have shown alterations with increasing body mass index (BMI), the extent and nature of such changes has varied substantially across studies. Here, we sought to determine whether small-scale morphometric measures might prove more sensitive and reliable than larger scale measures and whether they might offer a valuable opportunity to link cortical changes to underlying white matter changes. To examine this, we explored the association of BMI with millimetre-scale Gaussian curvature, in addition to standard measures of morphometry such as cortical thickness, surface area and mean curvature. We also assessed the volume and integrity of the white matter, using white matter signal intensity and fractional anisotropy (FA). We hypothesised

SUBMITTER: Medic N 

PROVIDER: S-EPMC6462878 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature