Defining Kinetic Properties of HIV-Specific CD8⁺ T-Cell Responses in Acute Infection.

ABSTRACT: Multiple lines of evidence indicate that CD8 + T cells are important in the control of HIV-1 (HIV) replication. However, CD8 + T cells induced by natural infection cannot eliminate the virus or reduce viral loads to acceptably low levels in most infected individuals. Understanding the basic quantitative features of CD8 + T-cell responses induced during HIV infection may therefore inform us about the limits that HIV vaccines, which aim to induce protective CD8 + T-cell responses, must exceed. Using previously published experimental data from a cohort of HIV-infected individuals with sampling times from acute to chronic infection we defined the quantitative properties of CD8 + T-cell responses to the whole HIV proteome. In contrast with a commonly held view, we found that the relative number

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6462943 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature