Towards the Development of Artificial Bone Grafts: Combining Synthetic Biomineralisation with 3D Printing.

ABSTRACT: A synthetic technique inspired by the biomineralisation process in nacre has been previously reported to be effective in replicating the nanostructural elements of nacre in 2D chitosan hydrogel films. Here we evaluate the applicability of this synthetic biomineralisation technique, herein called the McGrath method, in replicating the flat tabular morphology of calcium carbonate and other nanostructural elements obtained when 2D chitosan hydrogel films were used, on a 3D porous chitosan hydrogel-based scaffold, hence developing 3D chitosan-calcium carbonate composites. Nozzle extrusion-based 3D printing technology was used to develop 3D porous scaffolds using chitosan hydrogel as the printing ink in a custom-designed 3D printer. The rheology of the printing ink and print parameters were opt

SUBMITTER: Kurian M 

PROVIDER: S-EPMC6462944 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature