Genome-Wide Copy Number Variation Association Study of Atrial Fibrillation Related Thromboembolic Stroke.

ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia and is one of the major causes of ischemic stroke. In addition to the clinical factors such as CHADS2 or CHADS2-VASC score, the impact of genetic factors on the risk of thromboembolic stroke in patients with AF has been largely unknown. Single-nucleotide polymorphisms in several genomic regions have been found to be associated with AF. However, these loci do not contribute to all the genetic risks of AF or AF related thromboembolic risks, suggesting that there are other genetic factors or variants not yet discovered. In the human genome, copy number variations (CNVs) could also contribute to disease susceptibility. In the present study, we sought to identify CNVs determining the AF-related thromboembolic risk. Using a genome-wide appr

SUBMITTER: Hsieh CS 

PROVIDER: S-EPMC6463198 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature