Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation.

ABSTRACT: The functionally tolerated sequence space of proteins can now be explored in an unprecedented way, owing to the expansion of genomic databases and the development of high-throughput methods to interrogate protein function. For signaling proteins, several recent studies have shown how the analysis of sequence variation leverages the available protein-structure information to provide new insights into specificity and allosteric regulation. In this Review, we discuss recent work that illustrates how this emerging approach is providing a deeper understanding of signaling proteins.

SUBMITTER: Shah NH 

PROVIDER: S-EPMC6463301 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature