Phorbol 12-Myristate 13-Acetate-Induced Changes in Chicken Enterocytes.

ABSTRACT: Increased intestinal epithelial permeability has been linked to many enteric diseases because it allows easy access of microbial pathogens and toxins into the system. In poultry production, the restrictions in the use of antibiotic growth promoters have increased the chances of birds being susceptible to different enteric diseases. Thus, understanding the mechanisms which compromise intestinal function is pertinent. Based on our previous observation which showed the primary chicken enterocytes in culture undergoing dystrophic changes on treatment with phorbol myristate acetate (PMA), we surmised that this model, which appeared to mimic increased intestinal permeability, may help to understand the mechanisms of this problem. As genomic and proteomic changes are associated with many physiolo

SUBMITTER: Rath NC 

PROVIDER: S-EPMC6463336 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature