"Stem cell therapy to promote limb function recovery in peripheral nerve damage in a rat model" - Experimental research.

ABSTRACT:

Background

Optimizing nerve regeneration and mitigating muscle atrophy are the keys to successful outcomes in peripheral nerve damage. We investigated whether mesenchymal stem cell (MSC) therapy can improve limb function recovery in peripheral nerve damage.

Materials and methods

We used sciatic nerve transection/repair (SNR) and individual nerve transection/repair (INR; branches of sciatic nerve - tibial, peroneal, sural) models to study the effect of MSCs on proximal and distal peripheral nerve damages, respectively, in male Lewis rats. Syngeneic MSCs (5 × 10⁶; passage≤6) or saline were administered locally and intravenously. Sensory/motor functions (SF/MF) of the limb were assessed.

Results

Rat MSCs (>90%) were CD29⁺, CD90⁺, CD34

SUBMITTER: Bingham JR 

PROVIDER: S-EPMC6463551 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature