Retinopathy and RAAS Activation: Results From the Canadian Study of Longevity in Type 1 Diabetes.

ABSTRACT:

Objective

The importance of renin-angiotensin-aldosterone system (RAAS) activation in retinopathy for long-standing diabetes is not well understood. We determined retinopathy stage and evaluated associations with other vascular complications before and after physiological RAAS activation in adults with long-standing (≥50 years duration) type 1 diabetes.

Research design and methods

Participants underwent retinal examination by digital funduscopic photography and optical coherence tomography and were classified as having nonproliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), or no diabetic retinopathy (NDR) with or without diabetic macular edema (DME). Neuropathy was measured by clinical neuropathy examination scores, electrophysiologically, an

SUBMITTER: Lovshin JA 

PROVIDER: S-EPMC6463750 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature