Insulin/IGF1 signalling mediates the effects of β₂ -adrenergic agonist on muscle proteostasis and growth.

ABSTRACT:

Background

Stimulation of β₂ -adrenoceptors can promote muscle hypertrophy and fibre type shift, and it can counteract atrophy and weakness. The underlying mechanisms remain elusive.

Methods

Fed wild type (WT), 2-day fasted WT, muscle-specific insulin (INS) receptor (IR) knockout (M-IR^-/- ), and MKR mice were studied with regard to acute effects of the β₂ -agonist formoterol (FOR) on protein metabolism and signalling events. MKR mice express a dominant negative IGF1 receptor, which blocks both INS/IGF1 signalling. All received one injection of FOR (300 μg kg^-1 subcutaneously) or saline. Skeletal muscles and serum samples were analysed from 30 to 240 min. For the study of chronic effects of FOR on muscle plasticity and function as w

SUBMITTER: Goncalves DA 

PROVIDER: S-EPMC6463755 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature