Unknown

Dataset Information

0

SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

ABSTRACT: How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.

SUBMITTER: Schmitt K 

PROVIDER: S-EPMC6464631 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

Schmitt Kimberly K   Curlin James J   Kumar Dipu Mohan DM   Remling-Mulder Leila L   Feely Stephanie S   Stenglein Mark M   O'Connor Shelby S   Marx Preston P   Akkina Ramesh R  

Journal of medical primatology 20181001 5

How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4<sup>+</sup> T cells and adaptive genetic changes were observed during serial passages. ...[more]