Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.

ABSTRACT:

Objectives

Observational studies suggest obesity is associated with sepsis survival, but these studies are small, fail to adjust for key confounders, measure body mass index at inconsistent time points, and/or use administrative data to define sepsis. To estimate the relationship between body mass index and sepsis mortality using detailed clinical data for case detection and risk adjustment.

Design

Retrospective cohort analysis of a large clinical data repository.

Setting

One-hundred thirty-nine hospitals in the United States.

Patients

Adult inpatients with sepsis meeting Sepsis-3 criteria.

Exposure

Body mass index in six categories: underweight (body mass index < 18.5 kg/m), normal weight (body mass index = 18.5-24.9 kg/m), overweight (body mass index =

SUBMITTER: Pepper DJ 

PROVIDER: S-EPMC6465121 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature