Phosphite Esters: Reagents for Exploring S-Nitrosothiol Chemistry.

ABSTRACT: The reactions between S-nitrosothiols and phosphite esters, including P(OPh)₃, P(OBn)₃, and P(OEt)₃, were studied. Two different conjugated adducts, thiophosphoramidates and phosphorothioates, were formed, depending on the structures of the S-nitrosothiol substrate (e.g., primary vs tertiary). These reactions proceeded under mild conditions, and the reaction mechanisms were studied using experiments and calculations.

SUBMITTER: Liu C 

PROVIDER: S-EPMC6465146 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature