Temperature-Dependent Nuclear Spin Relaxation Due to Paramagnetic Dopants Below 30 K: Relevance to DNP-Enhanced Magnetic Resonance Imaging.

ABSTRACT: Dynamic nuclear polarization (DNP) can increase nuclear magnetic resonance (NMR) signal strengths by factors of 100 or more at low temperatures. In magnetic resonance imaging (MRI), signal enhancements from DNP potentially lead to enhancements in image resolution. However, the paramagnetic dopants required for DNP also reduce nuclear spin relaxation times, producing signal losses that may cancel the signal enhancements from DNP. Here we investigate the dependence of ¹H NMR relaxation times, including T_1ρ and T₂, under conditions of Lee-Goldburg ¹H-¹H decoupling and pulsed spin locking, on temperature and dopant concentration in frozen solutions that contain the trinitroxide compound DOTOPA. We find that relaxation times become longer a

SUBMITTER: Chen HY 

PROVIDER: S-EPMC6465147 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature