Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC6465305 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Liu Peidang P Shao Huimin H Ding Xuecheng X Yang Ruilong R Rui Qi Q Wang Dayong D
Scientific reports 20190415 1
Exposure to graphene oxide (GO) induced some dysregulated microRNAs (miRNAs), such as the increase in mir-247, in nematode Caenorhabditis elegans. We here further identified goa-1 encoding a Gαo and pkc-1 encoding a serine/threonine protein kinase as the targets of neuronal mir-247 in the regulation of GO toxicity. GO exposure increased the expressions of both GOA-1 and PKC-1. Mutation of goa-1 or pkc-1 induced a susceptibility to GO toxicity, and suppressed the resistance of mir-247 mutant to G ...[more]