¹⁸F-Flortaucipir in TDP-43 associated frontotemporal dementia.

ABSTRACT: Retention of ¹⁸F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if ¹⁸F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent ¹⁸F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer's Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using ³H-Flortaucipir was performed. SvPPA patients exhibited higher ¹⁸F-Flortaucipir retention in the lateral

SUBMITTER: Smith R 

PROVIDER: S-EPMC6465310 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature