3D visualisation of hepatitis B vaccine in the oral delivery vehicle SBA-15.

ABSTRACT: Developing a technology that enables oral vaccines to work efficiently remains a considerable effort since a number of difficulties must be addressed. The key objective being to ensure the safe passage through the harsh conditions within the gastrointestinal tract, promoting delivery that induces enhanced immune response. In the particular case of hepatitis B, the oral formulation in the nanostructured silica SBA-15 is a viable approach. As a result of its porous structure, low toxicity and structural stability, SBA-15 is capable to protect and release the hepatitis B surface antigen (HBsAg), used in the vaccination scheme, at the desired destination. Furthermore, when compared to the currently used injection based delivery method, better or similar antibody response has been observed. How

SUBMITTER: Rasmussen MK 

PROVIDER: S-EPMC6465313 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature