Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity.

ABSTRACT: Estrogen receptor alpha (ERα) is a sex hormone nuclear receptor that regulates various physiological events, including the immune response. Although there have been some recent studies on ERα regarding subsets of T cells, such as Th1, Th2, Th17, and Treg cells, its role in follicular helper T (TFH) cells has not yet been elucidated. To determine whether ERα controls TFH response and antibody production, we generated T cell-specific ERα knockout (KO) mice by utilizing the CD4-Cre/ERα flox system (CD4-ERα KO) and then analyzed their phenotype. At approximately 1 year of age, CD4-ERα KO mice spontaneously showed mild autoimmunity with increased autoantibody production and CD4⁺CD44⁺CXCR5⁺Bcl-6⁺ TFH cells in the mesenteric lymph nodes and spleen. We n

SUBMITTER: Kim DH 

PROVIDER: S-EPMC6465332 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature